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The Art in Science

Product Image Bend to the Will of the Cell

Bend to the Will of the Cell

Jianping Fu, Ph.D., Assistant Professor, Mechanical Engineering

Our laboratory uses bioengineering techniques to study the effects of the environment on cell structure and function. Here, we have microengineered a silicone substrate composed of many post-like structures. The tops of the posts are coated with a protein to which cells readily adhere. In this experiment, we tested how human mesenchymal stem cells (MSCs) respond to posts of different rigidity. MSCs have to potential to give rise to either fat cells or bone cell. Interestingly, when MSCs were place on rigid posts, they made bone; on soft posts, they made fat! We are now studying how force transduction tells cells which fate to choose.

Dimensions:

Print Size Approximate Total Size With Mat or Mat/Frame
5x7 9x11
5x12 11x18
8x10 12x14
11x14 15x18
16x20 20x24